Abstract: Skull bone plays a significantly important role in sustaining life safety. As a cellular sandwich structure, skull bone is composed of compact bone (panel) and cancellous bone (core). Through the interaction between the skull section and impactor, the variation tendency of energy absorption of human skull bone with impact velocity has been analyzed based on energy conservation law in this paper. The failure topography of the skull bone under different impact velocities has been provided, and the structural energy absorption characteristics also have been reflected according to the failure area of the skull section.