Abstract: In response to the special needs of the COVID-19 epidemic and the general trend of digital development, the reform and practice of online and offline blended courses have received more and more attention. This paper mainly discussed the online and offline blended course reform and practice methods of computational fluid dynamics (CFD), and puts forward the reform methods of offline theory teaching, online case teaching, and online and offline blended teaching. At the same time, the ideological and political elements of the course are introduced to imperceptibly stimulate students' patriotic enthusiasm and national spirit, encourage students to use computational fluid dynamics to solve bottleneck problem, and realize the unity of professional knowledge, engineering application, and national development.