Abstract: The transition of oil-water two phase flow in the tube from stratified flow to dispersed flow is known to be mainly caused by the change of interface wave form. However, the underlying mechanism of such transition is still unknown. Therefore, based stability condition on the amplitude of fluctuation, this paper adopted a sine wave model for the interface wave of oil-water two-phase stratified flow. According to the force balance, a computational model for of the external force in the flow direction of the interface wave is proposed. Then the critical prediction equation for the deformation and failure is given, from which the state of interfacial wave can be determined. Through numerical fitting, it is found that the deformation of the oil-water interface wave is related to the dip angle of the pipeline and the velocities of the two phases, and that the damage level is proportional to the wavelength and dip angle of the pipeline. The results are of great significance for improving oil and water transport efficiency.