Abstract: Pressure ports fault is an unavoidable engineering problem for the flush air data sensing (FADS) system. Effect of pressure ports fault on algorithm accuracy of the FADS system applied to flight vehicle with sharp wedged fore-bodies is investigated in this paper. Solving model and algorithm of the FADS system applied to the vehicle with sharp wedged fore-bodies is obtained based on the artificial neural network modeling, and the effect of stagnation pressure on solving algorithm accuracy is analyzed. Artificial failure in the pressure ports is set up to evaluate the pressure ports configuration's effect on the solving accuracy of the FADS system. Finally, threshold error distribution for each pressure port is determined which can assure the solving accuracy level. The results show that stagnation pressure and the pressure ports located on the windward areas has great effect on the solving accuracy of the FADS system. Proper correction of the faulty inputs with near pressure port located on the same windward or leeward areas can reduce the effect of failed pressure ports on the solving accuracy. Redundancy configuration will significantly increase the robustness of the FADS system, and broaden its application field.