Abstract: This paper introduced a new design for the measurement of solid-liquid interface friction resistance, which combines direct sensor measurement and the classic experimental method of flow pressure difference. This newly designed device was used to measure the friction resistance of the acrylic surface and lotus leaf surface. The results show that the data obtained by the flow pressure difference method and the direct measurement method are in good agreement, and the error of the surface friction resistance measured by the two methods is less than 2%. The friction resistance of the channel surface pasted with lotus leaves is always smaller than that of the acrylic channel surface, which reveals the effect of lotus leaf on the drag reduction.