Abstract: In a numerical simulation of microscale flow, it is difficult to reasonablly handle the interaction between microscopic particles and to improve computational efficiency. This paper discusses the Shan-Chen-type lattice Boltzmann method and its implementation. The applications of the model in various microfluidic situations are reviewed, and the effectiveness of the model is analyzed. The simulations show that Shan-Chen-type lattice Boltzmann method is easy to be implemented with the micro force and has capability and efficiency in computational microfluidics, and its applications are prospected. At the same time, because of easiness in dealing with wettability boundary, Shan-Chen-type lattice Boltzmann method has experienced tremendous advances in microstructure simulation with slip effect.