Abstract: Numerical simulation method is adopted to simulate the mean wind pressure of Shanghai EXPO Meteo World Pavilion. Four turbulence models (RNG k-ε, SST-k-ω, SSG-RSM and BSL-RSM), appropriate for structural wind engineering, are applied in this paper and compared shape coefficient, overall superficial forces and moments, and turbulence energy. In addition, with the analysis on regularity and difference of wind flow characteristics, conclusion is obtained that SST-k-ω ,BSL-RSM and SSG-RSM has different advantage but RNG - k-εis the worse. Finally, mean wind pressure coefficient of the pavilion is researched under the conditions of with and without interference. The reason of wind interference is also analyzed.