Abstract: The development of "New Engineering Disciplines" is the initiative plan of China's higher education in the face of the fourth industrial revolution. Under the background of the engineering education reform, there are many problems in the undergraduate education at this stage, such as the outdated teaching materials, a single training mode, and the lack of innovation and cross-border integration. Taking the speciality of Process Equipment and Control of East China University of Science and Technology as an example, this paper puts forward the practice teaching mode of "one core, two wings, two wheel drive". The innovation and entrepreneurship is the main body (one core), and the office of academic affairs takes charges of the overall planning and the in-depth development of various colleges (two wings), so as to create an integrated high-quality scientific and technological innovation platform of "teaching, scientific research and innovation practice". The design of the cross spiral promotion of "theory teaching" and "innovation and entrepreneurship practice" is for the double wheel drive curriculum system, to achieve the "learning and doing" organic combination, complementing with each other, constantly improving the students' comprehensive quality and engineering practice level, and cultivating innovative talents.