Abstract: The fluid mechanics is a compulsory basic course for the undergraduate major of safety engineering category. Through innovating the teaching mode of safety engineering fluid mechanics theory, integrating professional disciplinary knowledge and reforming the practical teaching method, the overall teaching reform idea and plan are put forward. The core knowledge hierarchy of the safety engineering fuid mechanics is combed. A series of the seemingly isolated basics theoretic three formulas are linked. The knowledge points related to the safety engineering are extended. The ultimate goal of the teaching course is to make the student understand what to learn, how to learn and how to use the related knowledge in the safety engineering. In addition, the practice teaching link of the safety engineering is enriched. The self-made experiment is encouraged for students to conduct the exploratory discovery with an independent team formed. It is suggested to broaden the practice teaching form and method and guide students to carry out targeted virtual simulation experiments to improve the innovation ability of student.