Abstract: In view of the teaching characteristics of the Engineering Fluid Mechanics course, the teaching mode of "Theoretical Deduction—Experimental Study—Numerical Simulation—Interactive Case" is proposed. This teaching mode links the related knowledge points, with a variety of methods for explanation. Taking the boundary layer separation phenomenon as an example, the theoretical deduction is used to analyze its mechanism, the experimental method is applied to show the separation phenomenon, the CFD numerical simulation method is used for improving the teaching effect and expanding the knowledge, and the network interaction method is used to improve the learning interest and deepen understanding. The traditional and the emerging technologies are combined and this mode can be used for the teaching of other courses.