Abstract: The studies on discrete Boltzmann modeling and simulation of phase separation are reviewed. According to the system component, the studies cover the single-component two-phase separation and the multi-component phase separation. According to the physical modeling, the studies cover the LBM (lattice Boltzmann method) simulations based on traditional hydrodynamic modeling and discrete kinetic modeling of the phase separation system. According to the main focus, the topic covers method/model studies and physical behavior investigations. The discrete kinetic modeling has brought some deeper insights into the phase separation process. The features of non-equilibriums obtained from discrete Boltzmann simulations can serve as some simple and effective physical criteria for dividing the two stages of phase separation, and can be used to discriminate and track various interfaces.