Abstract: At the beginning of this century, the lunar exploration programs Constellation, Aurora and Chang'e are proposed by NASA(National Aeronautics and Space Administration), ESA(European Space Agency) and CAST(China Academy of Space Technology), respectively. They open a new page for human being returning to space, and pose new requirements for the manned lunar mission. These requirements include more diversified detection scope, more accurate trajectory design and more strict safety measures for human crew. These make the program more complicated and sophisticated. This paper reviews in detail the developments of manned lunar mission's trajectory, Earth——Moon transfer trajectory, autonomous rendezvous guidance and lunar global coverage design, and presents the relevant hot topics in these fields. Finally, this paper outlines the tendency of future researches on this direction.