Abstract: Reducing the structural weight and enhancing the effective load of all kinds of aircrafts are the eternal subjects for designers all long. As regards that the air vehicles are usually in a special and complex service environment, one or more functions should be also given consideration except to the carrying capacity of the structures is designed. This article presents a comprehensive review on integrated design of lightweight multifunctional sandwich structures, which can realize loading and other multifunction, such as thermal control, heat protection, electron effect, stealth technique, energy absorption, actuating, energy storage, damping etc. This paper pools all those studies of lightweight multifunctional sandwich structures in the field of satellites, unmanned air vehicles and hypersonic space vehicles and so on. At last, the development tendency of lightweight lattice truss multifunctional structures is pointed out.