力学与实践 ›› 2020, Vol. 42 ›› Issue (3): 337-343.DOI: 10.6052/1000-0879-19-479

• 应用研究 • 上一篇    下一篇

基于膜理论的细胞压痕力学模型

王悦, 徐献忠1), 刘铭, 刘梦云   

  1. 郑州大学力学与安全工程学院,郑州 450001
  • 收稿日期:2019-12-23 修回日期:2020-03-06 出版日期:2020-06-20 发布日期:2020-06-29
  • 通讯作者: 1) 徐献忠,教授,研究方向为生物力学和固体流变学。 E-mail:xianzhongxu@zzu.edu.cn

A MECHANICAL MODEL OF CELL DURING INDENTATION BASED ON MEMBRANE THEORY

WANG Yue, XU Xianzhong1), LIU Ming, LIU Mengyun   

  1. School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, China
  • Received:2019-12-23 Revised:2020-03-06 Online:2020-06-20 Published:2020-06-29

摘要: 基于膜理论和细胞压痕实验,本文提出了一种可用于分析细胞变形的新的力学模型,通过对乳胶球和聚氯乙烯(PVC)球进行宏观压痕试验、理论分析以及与不同细胞压痕试验曲线的比较,验证了细胞力学模型的适用性。同时,利用新模型对单个软骨细胞进行了具体的力学分析,得到了细胞的力学参数、细胞膜表面的应力分布等,为单细胞力学特性的研究提供了一种新思路。

关键词: 细胞, 膜理论, 压痕实验, 力学模型, 力学特性

Abstract: This paper proposes a mechanical model that can be used to analyze the deformation of the cell during indentation experiments based on the membrane theory. The mechanical model of the cell is validated through the macro-indentation tests on latex balls and PVC balls, the theoretical analysis and the comparison of the indentation testing curves of the different cells. At the same time, a specific mechanical analysis of the single chondrocytes is carried out by using the new model, and the mechanical parameters of the cell and the stress distribution on the surface of the cell membrane are obtained. A new idea is thus provided for the study of the mechanical properties of single cells.

Key words: cell, membrane theory, indentation experiments, mechanical model, mechanical properties

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