Abstract: A lattice Boltzmann method with the use of an interaction potential between neighboring lattice particles is applied to simulate the fluid flow in a 2-D wall-patterned pipe. The simulation results indicate that the surface wettability, the surface roughness, the pressure and the fluid viscosity are the factors dominating the liquid-solid slip. The friction is reduced in the wall-patterned pipe under a low pressure. The simulation results can explain the existence of a threshold pressure gradient in mining underground reservoirs as well.